Glucocorticoid receptor interactome

Insight into glucocorticoid receptor signalling through interactome model analysis

Glucocorticoid hormones (GCs) are used to treat a variety of diseases because of their potent anti-inflammatory effect and their ability to induce apoptosis in lymphoid malignancies through the glucocorticoid receptor (GR). Despite ongoing research, high glucocorticoid efficacy and widespread usage in medicine, resistance, disease relapse and toxicity remain factors that need addressing. Unders...

A2A adenosine receptor interacting partners (interactome)

Background The A2A adenosine receptor is a member of the G proteincoupled receptor family. It is known to posses several unique structural and functional features that differ from established signaling paradigms. Recently, the exceptionally long (>120 amino acids) C-terminus of the receptor has raised interest for its capacity to act as a binding site for several "accessory" proteins. In search...

The Interactome of the Glucocorticoid Receptor and Its Influence on the Actions of Glucocorticoids in Combatting Inflammatory and Infectious Diseases.

Glucocorticoids (GCs) have been widely used for decades as a first-line treatment for inflammatory and autoimmune diseases. However, their use is often hampered by the onset of adverse effects or resistance. GCs mediate their effects via binding to glucocorticoid receptor (GR), a transcription factor belonging to the family of nuclear receptors. An important aspect of GR's actions, including it...

The glucocorticoid receptor.

The glucocorticoid receptor resource

The glucocorticoid receptor resource focuses on the structure-function relationships of the glucocorticoid receptor. As well as links to sequence and bibliographic databases via the World Wide Web, the database contains sequence comparisons of receptors from different species and source information for glucocorticoid receptor clones, probes, cell lines and antibodies. The resource allows the el...